Denizli airport is about 45 minutes drive from the city. There is direct flight almost everyday from Istanbul usually in the morning and back to Istanbul in the evening both with Turkish Airlines. The ticket would cost approximately $60.
Driving time to the capital city of Ankara is approximately 7 hours.
Driving time to İzmir is approximately 3 hours, with special alertness to be preserved at all times during the extremely busy Denizli-Aydın section. The extension of İzmir-Aydın highway to Denizli, to better benefit the production hub that Büyük Menderes River valley is, remains announced since years. Initial infrastructure is laid in Aydın, but the rest is yet to come and the present Aydın-Denizli road, although straight and flat, has a very high level of traffic, especially trucks, with each town along the road possessing its own industrial zone.